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The cerebral cortex, or just cortex, is the outermost layer of nerve tissue in the brain of mammals. It plays an important role in memory, perception and consciousness. It receives and processes information from the senses, such as sight, touch or smell. The basis of this process are not yet completely understood. Jason Kerr, research group leader of the Network Imaging Group at the Max Planck Institute for Biological Cybernetics in T? Bingen and his colleagues from the same institute, Wolfgang Mittmann, Damian Wallace and Uwe Czubayko able simultaneously to image neuronal activity of many neurons with single cell resolution, more than twice as deep as previously achieved. In collaboration with Winfried Denk from the Department of Biomedical Optics at the Max Planck Institute for Medical Research in Heidelberg and scientists at the Howard Hughes Medical Institute in Ashburn, Virginia, they studied the neural cell activity in the layer L5b in adult rodents, as well as one of the output layers of the cortex, however, one one layer away from the cortex end.

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However, the vitamin E molecular having a long, winding, foregoing tail has said molecule from fitting of fixed and effective in the groove. ‘soon as we recognize how interact with the agent is and the protein, we asked how we can improve this interaction,’says Chen. E scientists found in that a relatively simple process to change of the molecule structure – at bottom blades the tail short – approved a tighter fit and enhances the agent the ability of cancer cells by five-to ten-fold killing in laboratory test. ‘Overall, findings are made of proof of principle to of this drug can to kill cancer cell a very makes does very few damage to healthy cells,’says Chen. Darrell E.

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