It really is a genetic disorder that triggers defective or missing Element VIII.

However, since these patients' immune systems have had no or low exposure to normal Aspect VIII, they are generally not completely tolerant to the replacement Factor VIII used to take care of their condition. As a consequence, up to 30 per cent of these patients develop Aspect VIII inhibitor antibodies. Apitope has, through its patented discovery platform, completed the extensive analysis work to confirm that both peptides in ATX-F8-117, derived from Aspect VIII, have the potential to treat and prevent inhibitor advancement in haemophilia A patients treated with Aspect VIII. Currently, there are few therapies open to help individuals with inhibitors producing the Apitope approach potentially life changing for patients. Commenting on the designation, Dr Keith Martin, CEO said: We are very very happy to receive Orphan Medicinal Item Designation by the EMA for ATX-F8-117 which underlines the necessity for an effective treatment for patients with haemophilia A.Then, using time-lapse microscopy methods, postdoctoral scientist Jennifer Gutzman noticed the form changes of specific cells as the neural tube constricted and dilated to create the early embryonic human brain. ‘We followed solitary cells as time passes to see what goes on during brain advancement, and discovered that a distinct band of cells at the midbrain-hindbrain boundary constrict basally to create the sharpened bend,’ says Gutzman, co-lead writer on the paper. This is an intriguing result, suggesting that the ‘inside-out’ basal constriction was involved with making the bend. ‘Nevertheless, we wondered if this constriction produced passively, as human brain cavities inflated with liquid and pushed the cells in order that it basally constricted,’ notes Ellie Graeden, co-lead writer and a graduate pupil in the Sive laboratory.

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