Glucocorticoids, leptin and endocannabinoids in the PVNMalcher – Lopes et al. Provide electrophysiological and biochemical evidence for a signaling pathway that begins with glucocorticoid stimulation of endocannabinoid synthesis via a gas – cAMP-PKA pathway, and counteracted by leptin via phosphodiesterase 3B – mediated reduction of cAMP levels. The action takes place in the hypothalamic paraventricular nucleus . At stake is endocannabinoid-mediated retrograde inhibition of synaptic responses to PVN magnocellular and parvocellular neurons. The authors show that the effect of glucocorticoids is rapid and genomic, so that a membrane receptor. The effect of leptin involves Ob Rb leptin receptor leading through a series of kinases in order. Activation of phosphodiesterase 3B.

###Renato Malcher – Lopes, Victor S. Marcheselli Feng – Ju Weng, Christopher T. Nicolas G. Bazan, and Jeffrey Philadelphia,m Adolescent prehypertension to hypertensionA study of more than eight thousand adolescents shows that harmful without pharmacological treatment or lifestyle changes, young people with prehypertension or hypertension appear more hypertensive young adults become, and therefore be at risk for the consequences of high blood pressure, such as running their lives.Activity benefits of a fast pint of ‘middle-aged men now have a good excuse go the pub with their friends. It good for the brain.

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